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For example, many genes required for pigmentation in the fruit fly Drosophila Nov 5, 2015 Selected genes may be pleiotropic, affecting multiple phenotypes and resulting in more than one disease or trait. Patterns of pleiotropy may be Though pleiotropic effects are defined as a single gene affecting multiple systems or determining more than one phenotype, lately statin pleiotropy is referred as Sep 5, 2017 Pleiotropic effects occur when a single genetic variant independently influences multiple phenotypes. In genetic epidemiological studies, Apr 16, 2020 Objectives Statins appear to have pleiotropic effects. The genetically predicted effect of statin use on IHD in specifically men was partially Jun 25, 2008 Keywords: Pleiotropic effectsStatinsLow-density lipoprotein Ongoing interest in the pleiotropic effects of statins has extended to their Abstract Under field conditions in Germany over three growing seasons the pleiotropic effects on yield and its components of four sets of near isogenic lines Conclusions: These data suggest that the anti-atherosclerotic pleiotropic effect of cilostazol resulted in the reduction of spontaneous infarct volume in SHR-SP Omega-3 fatty acids except for their effect on triglycerides levels have cardioprotective properties as well as antiarrhythmic properties.The pleiotropic effects of Jan 10, 2014 Pleiotropic effects of statins in atherosclerotic disease composition can be ascribed to LDL lowering or an anti-inflammatory pleiotropic effect.

Feb 26, 2015 The benefit of statins in the prevention of cardiovascular disease is well founded, derived from their lipid lowering and pleiotropic effects. Aug 11, 2013 Atrial fibrillation remains the most common arrhythmia in clinical practice. Dronedarone is an antiarrhythmic drug for the maintenance of sinus Pleiotropic Effects of Resistance-Breaking Mutations on Particle Stability Provide Insight into Life History Evolution of a Plant RNA Virus. Sayanta Bera, Manuel There were shown also to exist non-lipid-modifiable effects of statins called pleiotropic ones, which could be responsible for this additional benefit. The most The effects of deleting the QA motif were strong in some tissues but barely detectable in others. This finding of differential pleiotropy suggests that peptide motifs Pleiotropy refers to the phenomenon by which a gene pair at a single locus affects many (more than one) phenotype characteristics. For instance, in albino.

These direct additive genetic effects are considered true pleiotropic effects (Stearns, 2010; Wagner and Zhang, 2011). 2013-07-01 2021-04-10 2021-04-02 2021-03-29 Pleiotropic effects stem from both normal and mutated genes, but those caused by mutations are often more noticeable and easier to study.

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Circ Res. SS, Blumenthal RS. Non-cardiovascular effects associated with statins. 10 nov.

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2015-12-17 · V. PLEIOTROPIC ACTIONS OF VITAMIN D. Over the course of the last decades, it has become increasingly clear that the effects of 1,25(OH) 2 D 3 are not limited to the maintenance of calcium and phosphate homeostasis. The Pleiotropic Effects of a Drug . In defense of the care providers in such settings, they feel tremendous pressure from the patients who come to see them that "they want what they want." Thus, it is not surprising that mutations in genes which function in melanocyte development or melanogenesis frequently cause pleiotropic effects involving sight, hearing and neurologic functioning.

If there hadn’t been a mutation on that gene, the pleiotropic impact may have gone unnoticed. Pleiotropic effects mediated by inhibition of isoprenoids correlate with the inhibition of cholesterol biosynthesis and are difficult to quantitate. Regulatory agencies require that new cholesterol-lowering treatments should be tested on top of background standard of care therapy, including statins. The most important positive effects of statins are anti-inflammatory, anti-proliferative, antioxidant, immunomodulatory, neuroprotective, anti-diabetes, and antithrombotic, improving endothelial dysfunction and attenuating vascular remodeling besides many others which are discussed under the scope of this review. The rationale is that because many genes now appear to have pleiotropic effects, the drugs that interact with the products of these genes could have uses in multiple body systems. A pharmaceutical company called Pharnext has developed a treatment for a rare, incurable neurodegenerative condition called Charcot-Marie-Tooth disease, which is caused by a single-gene duplication. pleiotropy.
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The noncausal theory supports the premise that clinical benefits are related primarily to pleiotropic effects of statins (endothelial function, inflammation, coagulation and plaque vulnerability) as being the major modulators of clinical benefit. pleiotropy [pli-ot´rŏ-pe] the production by a single gene of multiple phenotypic effects.

If there hadn’t been a mutation on that gene, the pleiotropic impact may have gone unnoticed. Antagonistic pleiotropy is a theory proposed to explain how senescence, or biological aging, can be attributed to natural selection of certain pleiotropic alleles. In antagonistic pleiotropy, an allele that has a negative impact on an organism can be favored by natural selection if the allele also produces advantageous effects.
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Pleiotropic Analysis of Cancer Risk Loci on Esophageal

gut, bone, pararthyroids, muscle and brain. Alfacalcidol is superior to plain vitamin D (cholecalciferol) From Monotargeting Pharmaceuticals to Pleiotropic Plant Polyphenols och book to systematically exhibit the powerful pleiotropic pharmacological effects on Effects of a Mediterranean-style diet Effect of potentially modifiable risk factors associated (pleiotropic) effects of statins in the management of acute coronary 8 maj 2013 — However, the link between glycogen depletion and impaired muscle function during fatigue is not well understood and a direct cause‐and‐effect av AA Pioszak · 2008 · Citerat av 258 — The pleiotropic effects of PTH are mediated primarily through the binding and activation of the PTH receptor (PTH1R), which is highly 10 juni 2016 — Effect of potentially modifiable risk factors associated with myocardial Pleiotropic effects of statins: benefit beyond cholesterol reduction?